Doctors are increasingly concerned about young people seeking a high from sizzurp, a candy-flavored cough syrup concoction popularized by rap singers. Codeine is an opioid medication prescribed to reduce physical pain. It can cause feelings of relaxation, drowsiness, confusion, nausea, itchiness and constipation, especially if taken in large doses. The only 12-hour codeine-based cough syrup 1,2. Covers a full 24 hours in just 2 equal doses (80 mg of codeine) for adults 18 years of age or older 1 There are many medicines available over-the-counter and by prescription that people are warned not to mix with alcohol. When you mix certain medicines with alcohol, the side effects can range from mild to severe, and in some cases may result in death. To answer the question asked, yes tramadol can get you high but in order to get a strong opiate euphoria it would need to be taken in high doses ( not recommended ). Codeine and Sprite are discussed together because of something called “purple drank.” Purple drank is a way to abuse codeine and get high that involves mixing codeine and Sprite with ice and Jolly Rancher candies. Well, I just did. I'll let you know if I survive. (Not a joke). In all likelihood, low doses of both should be okay. Ibuprofen is a pain reliever and reduces inflammation. Codeine is an opiate used to treat pain, as a cough medicine, and for diarrhea. It is typically used to treat mild to moderate degrees of pain. Greater benefit may occur when combined with paracetamol (acetaminophen) or a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin or ibuprofen. Evidence does not support its use for acute cough. While in general, it’s not a good idea to mix alcohol and medication, there are a few drugs in particular that are especially risky. Codeine is used to relieve mild to moderate pain. It is also used, usually in combination with other medications, to reduce coughing. Codeine will help relieve symptoms but will not treat the cause of symptoms or speed recovery.